Qingdao Institute of Bioenergy and Bioprocess Technology - China
AUTHOR PROFILE
EDUCATION AND EARLY CAREER
Dr. Ma Honglei, a distinguished Professor and doctoral supervisor, completed his undergraduate studies at Jilin University in 2009. He furthered his academic journey by pursuing doctoral research at the Shanghai Institute of Materia Medica from 2011 to 2016. Following his Ph.D., he worked as a postdoctoral fellow and associate researcher at the same institute before joining Shandong University in 2021. In 2022, he transitioned to the Qingdao Institute of Bioenergy and Process at the Chinese Academy of Sciences.
RESEARCH FOCUS AND METHODS
Dr. Ma's research is centered on the molecular analysis of protein complex structures and their interactions. His expertise encompasses the use of advanced techniques such as crystallography and cryo-electron microscopy, integrated with structural biology methods. These techniques are pivotal in understanding the functions of biological macromolecules and elucidating receptor-ligand interaction mechanisms for pharmacological predictions.
PUBLICATIONS AND CITATIONS
Dr. Ma has made significant contributions to the field, with his research featured in leading journals including Cell Research, Nature Communications, Science Advances, and Cell Discovery. His publications have garnered over 1000 citations, reflecting the impact and recognition of his work in the scientific community.
AWARDS AND RECOGNITION
Dr. Ma Honglei has been acknowledged for his outstanding research contributions through various accolades. He has been selected for prestigious honors such as the Talent Program, Distinguished Researcher, and Youth Innovation Promotion Association of the Chinese Academy of Sciences. In addition, he was named a "Qilu Young Scholar" at Shandong University and received the President's Excellence Award from the Chinese Academy of Sciences in 2016.
GRANT FUNDING AND PROJECT LEADERSHIP
Dr. Ma has successfully led numerous high-profile research projects, with funding exceeding 10 million yuan. His projects have been supported by the National Natural Science Foundation of China, the China Postdoctoral Foundation, the Shanghai Municipal Science and Technology Commission, major special projects of the Shandong Energy Research Institute, and subprojects of the Shandong Laboratory.
KEY PUBLICATIONS
Among his influential publications are "Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3" in Cell Discovery (2022), "Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor" in Nature Communications (2021), and "Structural insights into the activation of GLP-1R by a small molecule agonist" in Cell Research (2020). These papers highlight his contributions to understanding receptor mechanisms and protein interactions.
HONORS AND ACHIEVEMENTS
In recognition of his exemplary research, Dr. Ma has received the Outstanding Young Talent Award from the Shanghai Institute of Life Sciences of the Sanofi-Chinese Academy of Sciences in 2020. His achievements underscore his commitment to advancing scientific knowledge and his leadership in the field of structural biology.
NOTABLE PUBLICATION
Title: Molecular Insights into Ligand Recognition and Activation of Chemokine Receptors CCR2 and CCR3
Authors: Shao, Z., Tan, Y., Shen, Q., Zhang, Y., Shen, H.
Year: 2022
Journal: Cell Discovery
Title: Structural Insights into the Ligand Binding and Gi Coupling of Serotonin Receptor 5-HT5A
Authors: Tan, Y., Xu, P., Huang, S., Xu, H.E., Jiang, Y.
Year: 2022
Journal: Cell Discovery
Title: Identification and Mechanism of G Protein-Biased Ligands for Chemokine Receptor CCR1
Authors: Shao, Z., Shen, Q., Yao, B., Zhang, Y., Shen, H.
Year: 2022
Journal: Nature Chemical Biology
Title: Molecular Insights into Ago-Allosteric Modulation of the Human Glucagon-Like Peptide-1 Receptor
Authors: Cong, Z., Chen, L.-N., Ma, H., Zhang, Y., Wang, M.-W.
Year: 2021
Journal: Nature Communications
Title: Structural Insights into the Activation of GLP-1R by a Small Molecule Agonist
Authors: Ma, H., Huang, W., Wang, X., Yuan, D., Xu, H.E.
Year: 2020
Journal: Cell Research