Caroline Hoemann | Chronic Disease | Best Researcher Award

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Prof. Dr Caroline Hoemann | Chronic Disease | Best Researcher Award

Professor at George Mason University, United States

Dr. Caroline D. Hoemann is a Full Professor of Bioengineering at George Mason University, renowned for her groundbreaking work in tissue engineering and regenerative medicine. With a career spanning over three decades, she has made significant contributions to cartilage repair, biomaterials, and chronic inflammatory diseases. Dr. Hoemann co-invented BST-CarGel®, a chitosan-based biomaterial for cartilage repair, which has been successfully translated to clinical use. She is also a co-founder of ChitogenX, a biotech company focused on innovative medical solutions. Her research explores the intersection of inflammation, tissue regeneration, and advanced imaging techniques. Recognized globally, she has received numerous awards, including the Lifetime Achievement Award from the International Cartilage Repair Society. Dr. Hoemann’s work bridges academia and industry, fostering collaborations that drive innovation in biomedical engineering.

Professional Profile

Google Scholar

Education 🎓

Dr. Hoemann holds a B.A. in Chemistry and Biochemistry from the University of California, San Diego (1983), an M.Sc. in Applied Biology from MIT (1987), and a Ph.D. in Toxicology from MIT (1992). She completed postdoctoral training in Molecular Cell Biology at INSERM U309, Grenoble, France (1993), and the Friedrich-Miescher Institute, Basel, Switzerland (1994). Her academic foundation in chemistry, biology, and toxicology, combined with advanced training in molecular cell biology, has equipped her with a multidisciplinary approach to biomedical research.

Experience  💼

Dr. Hoemann has held prestigious positions, including Full Professor at George Mason University (2017–present) and École Polytechnique de Montréal (2013–2018). She served as Research Director at BioSyntech Ltd. (1998–2002) and Senior Scientist at IRCM, Montreal (1995–1997). She co-founded ChitogenX and has been a scientific advisor to multiple biotech firms. Her expertise spans biomaterials, cartilage repair, and chronic inflammation. Dr. Hoemann has also contributed to grant review panels for NIH and CIHR, and she mentors the next generation of scientists through her editorial roles and advisory board memberships.

Awards and Honors 🏆

Dr. Hoemann’s accolades include the Lifetime Achievement Award from the International Cartilage Repair Society (2023) and recognition as one of the world’s top 2% scientists in Orthopaedics/Biomedical Engineering by Stanford University (2020). She has received multiple FRQ-S Career Awards and served on NIH and CIHR grant review panels. Her editorial contributions to journals like Osteoarthritis & Cartilage Open and Cartilage highlight her leadership in the field. Dr. Hoemann’s patents, including the chitosan-based cartilage repair technology, have been widely cited, underscoring her impact on translational research.

Research Focus 🔬

Dr. Hoemann’s research focuses on understanding and harnessing inflammatory responses to promote tissue regeneration. Her work spans cartilage repair, biomaterials, and chronic inflammatory diseases like osteoarthritis and atherosclerosis. She pioneered chitosan-based biomaterials, such as BST-CarGel®, for cartilage repair, now used clinically. Her lab investigates how chronic inflammation leads to disease progression and explores advanced imaging techniques, like high-frequency ultrasound, to detect tissue remodeling. Collaborations with statisticians, clinicians, and engineers have led to discoveries in neutrophil behavior and myeloid-derived suppressor cells. Dr. Hoemann’s research bridges fundamental science and clinical applications, aiming to develop innovative therapies for tissue repair and chronic disease management.

Publication Top Notes 📚

  1. Charan A, Chitnis PV, Hoemann CD. Optimization of High-Frequency Ultrasound imaging to detect incremental changes in mineral content at the cartilage-bone interface ex vivo. Biomimetics (MDPI), in press.
  2. Leonard J, Kepplinger D, Espina V, Gillevet P, Ke Y; Birukov KG, Doctor A, Hoemann CD. Whole blood coagulation induces clot neutrophils to adopt a myeloid-derived suppressor cell signature and shed sLox-1. Journal of Thrombosis and Haemostasis, 2024: 22(4):1031-1045.
  3. Hoemann, C.D. Rodriguez Gonzáles J, Guzmán-Morales J, Chen G, Jalili Dil E, Favis B. Chitosan coatings with distinct innate immune bioactivities differentially stimulate angiogenesis, osteogenesis, and chondrogenesis in poly-caprolactone scaffolds with controlled interconnecting pore size. Bioactive Materials, 2022;10:430-442.
  4. Fong D, Grégoire-Gélinas P, Cheng AP, Mezheritsky T, Lavertu M, Sato S and Hoemann CD. Structurally distinct chitosans induce lysosomal rupture to promote either a type 1 IFN response or activate the inflammasome in macrophages. Biomaterials, 2017:129:127-38.

Conclusion 🌟

Dr. Caroline D. Hoemann is a trailblazer in bioengineering, whose work has transformed cartilage repair and advanced our understanding of inflammation in tissue regeneration. Her innovative chitosan-based biomaterials, impactful research, and leadership in the scientific community have earned her global recognition. Through her dedication to translational research and mentorship, she continues to inspire and shape the future of biomedical engineering.

 

Bassem Wadie | Health sciences | Best Researcher Award

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Prof Bassem Wadie | Health sciences | Best Researcher Award

Professor of urology, Director, Urology and Nephrology Center, Mansoura University, Egypt

Dr. Bassem S. Wadie is a Professor of Urology at Mansoura University, Egypt. With extensive expertise in urology, his clinical focus includes female urology, voiding dysfunction, and artificial intelligence in medicine. He has significantly contributed to research in urology, particularly in the areas of bladder dysfunction and prostate treatments. Dr. Wadie has been involved in groundbreaking clinical trials, including Phase I and II trials for FDA oversight devices and multi-center European studies. His work is recognized globally, having authored numerous publications in prestigious medical journals. His passion for advancing urological care is matched by his commitment to patient-centered research and clinical excellence.

Profile

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Orcid

Scopus

Strengths for the Award

  1. Extensive Research Experience:
    Dr. Bassem Wadie has a remarkable research track record, particularly in the field of urology. His involvement in Phase I and II trials for FDA oversight devices and participation in significant clinical studies like the SUNRISE multi-center European study highlights his leadership in innovative research. Additionally, his long-standing involvement with the Data and Safety Monitoring Board of the Urological Diseases Research Network (UITN) and his experience as a reviewer for grant applications for the NIH demonstrates his impact on global urological research.
  2. Wide Range of Research Focus Areas:
    Dr. Wadie’s research spans several critical areas in urology, such as female urology, voiding dysfunction, prostate treatments, urinary incontinence, and the application of artificial intelligence in urology. His work on clinical therapies like mid-urethral slings and prostate ablation devices reflects his comprehensive understanding of cutting-edge medical technology and patient care. His research is published in prestigious journals, consistently cited, which is a testament to the significance of his contributions.
  3. Clinical Impact and Innovation:
    Dr. Wadie’s research in clinical trials, such as the trials for new thermotherapy and prostate ablation devices, directly translates into improved treatment options for patients. His studies on urinary incontinence and bladder outlet obstruction have had lasting effects on surgical and non-surgical urological practices. The incorporation of artificial neural networks into predicting bladder outlet obstruction is a pioneering effort in integrating AI with urological diagnosis.

Areas for Improvements

  1. Broader Collaboration with Other Medical Disciplines:
    While Dr. Wadie has made significant strides in urology, collaborating with experts in other medical fields like cardiology or endocrinology could provide a more interdisciplinary approach to addressing overlapping health concerns, such as comorbidities affecting urological conditions.
  2. Increasing Public Awareness of Research:
    While Dr. Wadie’s publications are highly regarded in medical journals, there is an opportunity to further communicate the significance of his findings to the broader public and medical community. Engaging in more outreach initiatives or public health campaigns could amplify the impact of his research.
  3. Focus on Long-Term Post-Surgical Outcomes:
    Many of Dr. Wadie’s studies focus on the short-term outcomes of various urological surgeries and interventions. Expanding research to assess long-term effects, including patient quality of life over extended periods post-surgery, would provide invaluable insights into the sustainability of treatment outcomes.

Education

Dr. Bassem Wadie completed his primary education at the Divine Providence School in Mansoura, Egypt (1971–1978). He then attended El-Malek El-Saleh Preparatory School (1978–1981) and El-Malek El-Kamel High School (1981–1984), all in Mansoura. He graduated from Mansoura Faculty of Medicine with an M.B., B.Ch. in November 1990, earning a “very good” grade. Dr. Wadie further advanced his education with an M.Sc. in Urology in 1996 from Mansoura Urology & Nephrology Center and completed his M.D. in 2001, submitting a thesis on prostatic symptoms. His academic journey reflects a deep commitment to medical and scientific education, laying the foundation for his future contributions to urology.

Experience

Dr. Wadie’s career spans clinical, academic, and research domains. He was a principal investigator in several significant clinical trials, including Phase I and II trials for FDA-approved devices for prostate ablation (1999-2004) and the SUNRISE multi-center European study on Solifenacin (2004-2005). He also served on the Data and Safety Monitoring Board of the Urological Diseases Research Network (UITN) funded by the NIH/NIDDK. Furthermore, Dr. Wadie reviewed grant applications for the Lower Urinary Tract Dysfunction Network at the NIH in 2013. His extensive research in urology, particularly in bladder dysfunction and prostate treatments, has contributed to advancements in clinical urology.

Awards and Honors

Dr. Bassem Wadie has earned multiple honors throughout his distinguished career in urology. He was recognized for his contributions to clinical trials and urological research, especially in prostate ablation technologies and overactive bladder treatments. His work has been cited in leading international journals, earning him recognition as a respected researcher and clinician. He received special acknowledgment for his involvement in pioneering studies on urinary incontinence, bladder outlet obstruction, and therapeutic innovations. Dr. Wadie’s excellence in both research and patient care has garnered him a reputation as one of Egypt’s leading urologists, contributing to the global understanding of urological conditions.

Research Focus

Dr. Wadie’s research focuses on advancing the understanding and treatment of urological disorders, particularly in female urology, voiding dysfunction, and the application of artificial intelligence in diagnosis and treatment. He has pioneered studies on prostate ablation and bladder dysfunction treatments, including phase trials for new medical devices and therapies. His work is committed to improving patient outcomes through non-invasive diagnostic tools and personalized treatment strategies. Dr. Wadie is also dedicated to studying the impact of various surgical procedures, such as midurethral slings and Burch colposuspension, on urinary incontinence and quality of life. His research aims to improve clinical practices and inform global urological standards.

Publication Top Notes

  1. Retropubic versus transobturator midurethral slings for stress incontinence 📘
  2. Burch Colposuspension versus Fascial Sling to Reduce Urinary Stress Incontinence 📘
  3. Once daily trospium chloride is effective for overactive bladder 📘
  4. An adjustable continence therapy device for treating incontinence after prostatectomy 📘
  5. Autologous fascial sling vs polypropylene tape at short-term followup 📘
  6. The relationship of the International Prostate Symptom Score and bladder outlet obstruction 📘
  7. The relationship of detrusor instability and symptoms with bladder outlet obstruction 📘
  8. Bladder erosion of tension-free vaginal tape as vesical stone 📘
  9. Urinary incontinence management costs after Burch or sling surgery 📘
  10. TOT for stress urinary incontinence: assessing equivalence with TVT 📘
  11. Minimum 2-year follow-up of mid-urethral slings and quality of life 📘
  12. Application of artificial neural network in prediction of bladder outlet obstruction 📘
  13. Standard Snodgrass technique in hypospadias repair 📘
  14. TVT versus TOT: 2-year prospective randomized study 📘
  15. Urethral pressure measurement in stress incontinence 📘
  16. Severe stress urinary incontinence: objective analysis of risk factors 📘
  17. High-energy transurethral microwave thermotherapy: symptomatic vs urodynamic success 📘
  18. Dorsal dartos flap in Snodgrass hypospadias repair 📘
  19. Primary Nocturnal Enuresis Persistent to Adulthood, Functional Evaluation 📘

Conclusion

Dr. Bassem S. Wadie is an exemplary researcher whose work has made significant contributions to the field of urology. His innovative approach to addressing complex urological issues, combined with his dedication to improving patient outcomes, makes him a highly deserving candidate for the Best Researcher Award. His research on prostate ablation, female urology, and the application of AI in diagnosis showcases his commitment to advancing medical knowledge. With continued focus on interdisciplinary collaboration and public engagement, Dr. Wadie’s research has the potential to influence global urological practices and patient care for years to come.