Liu Jun - Fundamental research - Excellence in Research

Chongqing Medical University - China

NOTABLE PUBLICATION

SCOPUS

🎓 EDUCATION BACKGROUND

Liu Jun received a bachelor's degree from Southwest Medical University in 2016 and later earned a master's degree from Chongqing Medical University in 2024. Specializing in integrated Chinese and Western medicine, Liu Jun is an attending doctor in Internal Medicine, with a particular focus on the prevention and treatment of chronic kidney disease. His academic journey has provided a strong foundation in both traditional Chinese medicine and modern medical practices, allowing him to approach complex health issues with a holistic perspective.

🩺 RESEARCH INTERESTS

Liu Jun’s research is centered on the integration of Chinese and Western medicine for the prevention and treatment of chronic kidney disease (CKD). His work explores the therapeutic potential of combining traditional herbal remedies, such as Astragaloside IV, with modern medical techniques. By focusing on the synergistic effects of these two medical traditions, he aims to develop more effective treatments for CKD, particularly in the context of complex conditions like diabetic kidney disease (DKD).

🔬 KEY STUDY ON ASTRAGALOSIDE IV

Liu Jun has conducted groundbreaking research on Astragaloside IV (AS-IV), a bioactive compound from the Astragalus membranaceus root, used in Chinese medicine to treat CKD. His study revealed that AS-IV plays a significant role in the treatment of diabetic kidney disease by mitigating oxidative stress, ferroptosis, and mitochondrial dysfunction in renal tubular epithelial cells. This research provides new insights into the renoprotective mechanisms of AS-IV and highlights its potential for clinical application in DKD management.

🧬 RESEARCH METHODS AND FINDINGS

In his study, Liu Jun employed advanced research techniques, including network pharmacology, proteomics, molecular docking, and molecular dynamics simulation, to uncover the molecular mechanisms by which AS-IV exerts its protective effects. His findings demonstrated that AS-IV enhances renal function, reduces oxidative stress, and prevents mitochondrial damage in DKD models. The study also identified key proteins—HMOX1, FTH1, and TFR1—that interact with AS-IV, further supporting its role in combating mitochondrial dysfunction and ferroptosis in DKD.

📚 PUBLICATIONS

Liu Jun has published four SCI papers, each contributing to the understanding of integrated Chinese and Western medicine in the treatment of chronic kidney disease. His work on AS-IV and its effects on DKD has been particularly impactful, offering new avenues for the development of renoprotective therapies. His publications reflect a commitment to advancing the field of nephrology through innovative research that bridges traditional and modern medical practices.

🏅 CONTRIBUTIONS TO INTEGRATED MEDICINE

Through his research, Liu Jun is making significant contributions to the field of integrated Chinese and Western medicine. His work not only advances the scientific understanding of traditional herbal compounds like AS-IV but also paves the way for their integration into modern medical treatments. His research has the potential to improve patient outcomes by providing more comprehensive and effective therapies for chronic kidney disease, particularly in the context of diabetes.

🌟 PROFESSIONAL GOALS

Looking ahead, Liu Jun aims to continue his research in integrated medicine, focusing on the development of new strategies for the treatment of chronic kidney disease. His goal is to further explore the potential of traditional Chinese medicine in combination with Western medical approaches, ultimately contributing to the creation of more holistic and effective treatment options for patients with complex medical conditions like DKD.

NOTABLE PUBLICATION

A New Strategy for Astragaloside IV in the Treatment of Diabetic Kidney Disease: Analyzing the Regulation of Ferroptosis and Mitochondrial Function of Renal Tubular Epithelial Cells
Authors: Liu, J., Yang, K., Zhou, L., Zhang, Y., Cao, W.
Year: 2024
Journal: International Immunopharmacology

Proteomic and Lipidomic Analysis of the Mechanism Underlying Astragaloside IV in Mitigating Ferroptosis Through Hypoxia-Inducible Factor 1α/Heme Oxygenase 1 Pathway in Renal Tubular Epithelial Cells in Diabetic Kidney Disease
Authors: Liu, J., Ren, J., Zhou, L., Cao, W., Zhang, Y.
Year: 2024
Journal: Journal of Ethnopharmacology

Integration of Network Pharmacology and Serum Medicinal Chemistry to Investigate the Pharmacological Mechanisms of QiZhuYangGan Decoction in the Treatment of Hepatic Fibrosis
Authors: Deng, J.-W., Yuan, S., Shi, L.-P., Yang, Q., Cao, W.-F.
Year: 2024
Journal: Journal of Ethnopharmacology

EMPLOYMENT AND PROFESSIONAL EXPERIENCE

Syed Ayaz Ali Abid Ali is currently serving as an Associate Professor of Pharmacology at Y. B. Chavan College of Pharmacy, Aurangabad, a position he has held since January 2010. Prior to this, he served in the same capacity on an ad hoc basis from February 2008 to January 2010. His earlier roles include Assistant Professor and Incharge Principal at Royal College of Pharmaceutical Education and Research, Sayne, Malegaon, and as a Research Scientist at Ranbaxy Research Laboratories Ltd, Gurgaon from May 2005 to March 2007. He also contributed as a Lecturer at Hamdard University, New Delhi, from August 2001 to July 2004.

SUBJECTS TAUGHT

His academic contributions span a range of subjects in both undergraduate and postgraduate programs. At the undergraduate level, he has taught Anatomy, Physiology & Health Education, Pharmacology & Toxicology, Pharmacology and Bioassay, Clinical Pharmacy & Therapeutics, and Pharmacy Practice. For postgraduate students, he has covered Advanced Pharmacology, Methods in Pharmacology, Nanotechnology & Biotechnology.

ADMINISTRATIVE RESPONSIBILITIES

Dr. Ali has taken on numerous administrative roles throughout his career, including Member Secretary of the Institutional Animal Ethics Committee (IAEC), Academic Incharge, Admission Incharge, Animal House In-Charge, Head of Department, and various committee memberships such as the Discipline Committee and Women’s Grievances Committee. His contributions extend to serving on the Library Committee and undertaking responsibilities as a university assignment setter, examiner, moderator, and Center Superintendent for examinations.

UNIVERSITY ASSIGNMENTS

He has actively participated in university assignments, including serving as a Paper Setter, Expert for staff selection, PG teacher recognition, Ph.D. guide, and member of syllabus framing committees. He has chaired and participated in local inspection committees, vigilance squads, and acted as a Ph.D. thesis evaluator for Savitribai Phule Pune University. His expertise has also been recognized through nominations as a subject expert by various universities for staff selection processes.

EDUCATIONAL QUALIFICATIONS

Dr. Ali holds a Ph.D. in Pharmacology from Hamdard University, New Delhi, awarded in January 2005. He completed his M. Pharm. in Pharmacology from the same institution in November 2000 and earned his B. Pharm. from Dr. BAMU, Aurangabad, in June 1997. His secondary education includes achieving first-class distinctions in HSC Science from Aurangabad Board in June 1993 and SSC in June 1991.

RESEARCH GUIDANCE AND ACHIEVEMENTS

He has been actively involved in guiding students, having supervised 38 M. Pharm. theses and currently guiding 7 Ph.D. students at Dr. Babasaheb Ambedkar Marathwada University, Aurangabad. Dr. Ali has secured research grants, including a Seminar grant from the Indian Council for Medical Research (ICMR) in February 2012. He has also filed several patents, including innovations in drug delivery systems, cancer management formulations, and medical device designs.

PROFESSIONAL DEVELOPMENT AND RECOGNITION

Throughout his career, Dr. Ali has pursued continuous professional development through seminars, workshops, and research collaborations. His contributions to pharmaceutical research and education have been pivotal, marked by his publications and patents that contribute significantly to the field's advancement.

NOTABLE PUBLICATION

Neuroprotective effect of Feronia limonia on ischemia reperfusion induced brain injury in rats

Authors: PB Rakhunde, S Saher, SA Ali
Year: 2014

Influence of DL α-lipoic acid and vitamin-E against doxorubicin-induced biochemical and histological changes in the cardiac tissue of rats

Authors: SA Ayaz, U Bhandari, KK Pillai
Year: 2005

PH triggered sol-gel transition system of ofloxacin for prolonged gastric retention

Authors: SR Lahoti, RK Shinde, SA Ali, B Gulecha
Year: 2011

Cardioprotective and Antioxidant activity of Onion (Allium cepa) Leaves Extract in Doxorubicin Induced Cardiotoxicity in Rats

Authors: QN Nausheen, SA Ali, K Subur
Year: 2014

A Review: Zam Zam a miracle water

Authors: AVD Ahmad, SA Ali, T Sheikh, S Choas, R Bagwan
Year: 2018