Assist. Prof. Dr Chan-Yen Kuo | Tumor Immunology | Best Researcher Award

Principal investigator, Tzu Chi University, Taiwan

Chan-Yen Kuo is a distinguished researcher and academic in the field of Cancer Biology, based in Taiwan. With a PhD in Life Science from Tunghai University, Dr. Kuo has made significant contributions to understanding cancer mechanisms, particularly in oral cancer, renal cell carcinoma, and hepatic stellate cell activation. Currently, he serves as an Adjunct Associate Professor at Jenteh Junior College of Medicine, Nursing and Management and as an Associate Investigator at Taipei Tzu Chi Hospital. His work integrates molecular biology, pharmacology, and traditional medicine to develop innovative therapeutic strategies. Dr. Kuo is also an active contributor to scientific literature, with numerous publications in high-impact journals.

Professional Profile

Orcid

Scopus

Strengths for the Award 🏆

1. Prolific Research Output: Chan-Yen Kuo has an extensive publication record, with over 50 works in high-impact journals, demonstrating consistent contributions to the field of cancer biology and related areas. His research spans molecular mechanisms, therapeutic strategies, and the role of natural compounds in cancer treatment.
2. Interdisciplinary Approach: Dr. Kuo’s work integrates molecular biology, pharmacology, and traditional medicine, showcasing a unique ability to bridge gaps between disciplines. His research on natural compounds like chrysophanol and their anti-cancer effects highlights innovative approaches to therapy.
3. High-Impact Publications: Many of his papers are published in reputable journals such as Current Issues in Molecular Biology, Biomedicines, and Oxidative Medicine and Cellular Longevity, indicating the quality and relevance of his research.
4. Focus on Translational Research: His work has practical implications for cancer diagnostics and treatment, particularly in understanding cancer stem cells, metastasis, and the role of inflammation and oxidative stress in tumorigenicity.
5. Collaborative Efforts: Dr. Kuo frequently collaborates with other researchers, as evidenced by the numerous contributors listed in his publications. This demonstrates his ability to work in teams and contribute to larger scientific goals.
6. Diverse Research Topics: His research covers a wide range of topics, including oral cancer, renal cell carcinoma, hepatic stellate cell activation, and even COVID-19 mortality predictors, showcasing versatility and depth.

Areas for Improvement 📉

1. Citations and Impact Factor: While Dr. Kuo has a strong publication record, the citation counts and impact factors of some journals could be improved. Focusing on publishing in higher-impact journals could increase the visibility and influence of his work.
2. International Recognition: Although his work is significant, greater international collaboration or participation in global conferences could enhance his global recognition and impact.
3. Awards and Honors: There is limited information on specific awards or honors received by Dr. Kuo. Actively applying for prestigious awards or recognitions could further validate his contributions to the field.
4. Clinical Trials: While his research is highly translational, there is limited evidence of direct involvement in clinical trials. Engaging in clinical research could bridge the gap between laboratory findings and real-world applications.
5. Public Engagement: Increasing public engagement through science communication, interviews, or media appearances could help disseminate his research findings to a broader audience.

Education 🎓

Chan-Yen Kuo earned his PhD in Life Science from Tunghai University, Taichung, Taiwan, where he studied from 2004 to 2008. His doctoral research laid the foundation for his expertise in molecular biology and cancer research. During his academic journey, he developed a strong interest in the molecular mechanisms of cancer progression, particularly focusing on cell signaling pathways, oxidative stress, and inflammation. His educational background has equipped him with the skills to explore the intersection of traditional medicine and modern therapeutic approaches.

Experience 💼

Dr. Kuo has extensive experience in both academia and research. Since March 2022, he has been an Adjunct Associate Professor at Jenteh Junior College of Medicine, Nursing and Management, where he teaches and mentors students in medical technology. Additionally, since July 2021, he has served as an Associate Investigator at Taipei Tzu Chi Hospital, focusing on translational research in cancer biology. His previous roles include collaborations with various research institutions, where he investigated the role of bioactives, inflammation, and oxidative stress in cancer progression and therapy.

Awards and Honors 🏆

While specific awards and honors for Dr. Chan-Yen Kuo are not detailed in the provided information, his prolific publication record and leadership roles in cancer research indicate recognition within the scientific community. His work on topics such as EpCAM signaling, chrysophanol’s anti-cancer effects, and the role of inflammation in cancer has been widely cited, reflecting his impact on the field. Dr. Kuo’s contributions to high-impact journals and his involvement in cutting-edge research projects underscore his standing as a respected figure in cancer biology.

Research Focus 🔬

Dr. Kuo’s research focuses on understanding the molecular mechanisms of cancer progression and developing novel therapeutic strategies. His work spans several areas, including the role of cancer stem cells in metastasis, the impact of oxidative stress and inflammation on tumorigenicity, and the therapeutic potential of natural compounds like chrysophanol. He also explores the interplay between traditional medicine and modern pharmacology, aiming to identify bioactive compounds that can inhibit cancer cell growth, induce apoptosis, and modulate immune responses. His research has significant implications for improving cancer diagnostics and treatment.

Publication Top Notes 📚

1. EpCAM Signaling in Oral Cancer Stem Cells: Implications for Metastasis, Tumorigenicity, and Therapeutic Strategies
2. Molecular Biological Mechanisms of Action of Chrysophanol in Hepatic Stellate Cells Activated by Hepatic B Virus X Based on Network Pharmacology
3. Diagnostics and Therapy for Malignant Tumors
4. The Interplay between von Hippel–Lindau Tumor Suppressor Gene, Lon Protease, ROS Accumulation, and Inflammation in Clear Cell Renal Cell Carcinoma
5. The Promising Potential of Caulerpa microphysa in Dermatology
6. Tazarotene-induced Gene 1 Induces Melanoma Cell Death by Triggering Endoplasmic Reticulum Stress Response
7. The Role of Bioactives in Inflammation
8. Bioactives and Inflammation
9. The COVIDTW study: Clinical predictors of COVID-19 mortality and a novel AI prognostic model using chest X-ray
10. Pinostrobin and Tectochrysin Conquer Multidrug-Resistant Cancer Cells via Inhibiting P-Glycoprotein ATPase
11. The von Hippel-Lindau Tumor Suppressor Gene Mutations Modulate Lipocalin-2 Expression in Ferroptotic-Inflammatory Pathways
12. Pharmacological Interventions for Excessive Daytime Sleepiness in Adults with Narcolepsy: A Systematic Review and Network Meta-Analysis
13. Coumarin Derivatives Inhibit ADP-Induced Platelet Activation and Aggregation
14. Chrysophanol Suppresses Cell Growth via mTOR/PPAR-α Regulation and ROS Accumulation in Cultured Human Tongue Squamous Carcinoma SAS Cells
15. Combined Acupoints for the Treatment of Patients with Obesity: An Association Rule Analysis
16. Wild Bitter Melon Extract Abrogates Hypoxia-Induced Cell Death via the Regulation of Ferroptosis, ER Stress, and Apoptosis in Microglial BV2 Cells
17. An Association Rule Analysis of Combined Acupoints for the Treatment of Patients with Dry Eye Disease
18. An Association Rule Analysis of the Acupressure Effect on Sleep Quality
19. Nephroprotective Role of Chrysophanol in Hypoxia/Reoxygenation-Induced Renal Cell Damage via Apoptosis, ER Stress, and Ferroptosis
20. Poria cocos Regulates Cell Migration and Actin Filament Aggregation in B35 and C6 Cells by Modulating the RhoA, CDC42, and Rho Signaling Pathways
21. Tournefortia sarmentosa Inhibits the Hydrogen Peroxide-Induced Death of H9c2 Cardiomyocytes
22. Anti-Cancer Effects of Zotarolimus Combined with 5-Fluorouracil Treatment in HCT-116 Colorectal Cancer-Bearing BALB/c Nude Mice
23. Role of the Inflammatory Response of RAW 264.7 Cells in the Metastasis of Novel Cancer Stem-Like Cells
24. Wild Bitter Melon Extract Regulates LPS-Induced Hepatic Stellate Cell Activation, Inflammation, Endoplasmic Reticulum Stress, and Ferroptosis
25. Safflower Extract Inhibits ADP-Induced Human Platelet Aggregation
26. Interleukin-6 and Interleukin-8 Regulate STAT3 Activation Migration/Invasion and EMT in Chrysophanol-Treated Oral Cancer Cell Lines
27. The Anti-Cancer Effects of a Zotarolimus and 5-Fluorouracil Combination Treatment on A549 Cell-Derived Tumors in BALB/c Nude Mice
28. An Apriori Algorithm-Based Association Rule Analysis to Identify Acupoint Combinations for Treating Diabetic Gastroparesis
29. Poor Work Efficiency is Associated with Poor Exercise Capacity and Health-Related Quality of Life in Patients with Chronic Obstructive Pulmonary Disease
30. Loss of Function of von Hippel‐Lindau Trigger Lipocalin 2‐Dependent Inflammatory Responses in Cultured and Primary Renal Tubular Cells
31. Establishment of an Immunocompetent Metastasis Rat Model with Hepatocyte Cancer Stem Cells
32. Dietary Patterns and the Risk of Prediabetes in Taiwan: A Cross-Sectional Study
33. A Meta-Analysis of Comparing Intermittent Epidural Boluses and Continuous Epidural Infusion for Labor Analgesia
34. Wild Bitter Melon Exerts Anti-Inflammatory Effects by Upregulating Injury-Attenuated CISD2 Expression following Spinal Cord Injury
35. An Apriori Algorithm‐Based Association Rule Analysis to Identify Herb Combinations for Treating Uremic Pruritus Using Chinese Herbal Bath Therapy
36. Chrysophanol Prevents Lipopolysaccharide‐Induced Hepatic Stellate Cell Activation by Upregulating Apoptosis, Oxidative Stress, and the Unfolded Protein Response
37. Chrysophanol Regulates Cell Death, Metastasis, and Reactive Oxygen Species Production in Oral Cancer Cell Lines
38. Combination of Acupoints in Treating Patients with Chronic Obstructive Pulmonary Disease: An Apriori Algorithm‐Based Association Rule Analysis
39. Neuronal CISD2 plays a minor anti-inflammatory role in LPS-stimulated neuron-like SH-SY5Y cells
40. Oridonin Attenuates Lipopolysaccharide‐Induced ROS Accumulation and Inflammation in HK‐2 Cells
41. Role of Chrysophanol in Epithelial‐Mesenchymal Transition in Oral Cancer Cell Lines via a Wnt‐3‐Dependent Pathway
42. Danshensu Attenuates Hypoxia-Induced Reactive Oxygen Species Production and Inducible Nitric Oxide Synthase Expression in RAW 264.7 Cells
43. Prevotella denticola septic embolic cerebral infarction after difficult lower wisdom tooth extraction
44. Tazarotene-Induced Gene 1 (TIG1) Interacts with Serine Protease Inhibitor Kazal-Type 2 (SPINK2) to Inhibit Cellular Invasion of Testicular Carcinoma Cells
45. Apoptotic effects of hsian‐tsao (Mesona procumbens Hemsley) on hepatic stellate cells mediated by reactive oxygen species and ERK, JNK, and caspase‐3 pathways
46. Endothelial-cell inflammation and damage by reactive oxygen species are prevented by propofol via ABCA1-mediated cholesterol efflux
47. The protective effect of simvastatin against ultraviolet B-induced corneal endothelial cell death
48. UVB promotes the initiation of uveitic inflammatory injury in vivo and is attenuated by UV-blocking protection
49. VHL Inactivation in Precancerous Kidney Cells Induces an Inflammatory Response via ER Stress–Activated IRE1α Signaling

Conclusion 🎯

Chan-Yen Kuo is a highly accomplished researcher with a strong track record in cancer biology, particularly in understanding the molecular mechanisms of cancer progression and developing innovative therapeutic strategies. His interdisciplinary approach, high-quality publications, and collaborative efforts make him a strong candidate for the Best Researcher Award.

However, to further strengthen his candidacy, Dr. Kuo could focus on increasing the impact factor of his publications, seeking international recognition, and engaging in clinical trials or public outreach. Overall, his contributions to the field are significant, and with a few strategic improvements, he could solidify his position as a leading researcher in cancer biology.